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論文・発表

論文等

2024年

  • T. Yurino, Z. Wu, K. Suzuki, R. Nitta, Y. Sakaguchi, T. Ohkuma
    Asymmetric Cyanation of α-Ketimino Ester Derivatives with Chiral Ru–Li Combined Catalysts
    Org. Lett. 2024, 26, 900–905.
  • T. Yurino, R. Nishihara, T. Yasuda, S. Yang, N. Utsumi, T. Katayama, N. Arai, T. Ohkuma
    Asymmetric Hydrogenation of α-Alkyl-Substituted β-Keto Esters and Amides through Dynamic Kinetic Resolution
    Org. Lett. 2024, 26, accepted

2023年

  • T. Ishizaka, Y. Nakayama, T. Touge, Y. Yuki, K. Matsumura, T. Yurino, T. Ohkuma
    Ru(η1-BH4)(daipena)(diphosphine): Ruthenabicyclic borohydride complexes for asymmetric hydrogenation of ketones and asymmetric formatl hydroamination of allylic alcohols under base-free conditions
    Tetrahedron 2023, 149, 133705. 
  • T. Takashima, H. Ece, T. Yurino, T. Ohkuma
    Ag-Catalyzed Cyanomethylation of Amines Using Nitromethane as a C1 Source
    Org. Lett. 2023, 25, 6052–6055.
  • 大熊毅
    「ケトンの高活性不斉水素化触媒を求めて　－遷移状態モデルに基づいた試行錯誤」
    化学同人出版　有機合成化学協会編　「ドラマチック有機化学　感動の瞬間100」 p.156–157 （2023年7月30日出版）
  • H. Ishikawa, T. Yurino, R. Komatsu, M.-Y. Gao, N. Arai, T. Touge, K. Matsumura, T. Ohkuma
    Asymmetric Hydrogenation of α-Amino Esters into Optically Active β-Amino Alcohols through Dynamic Kinetic Resolution Catalyzed by Ruthenabicyclic Complexes
    Org. Lett. 2023, 25, 2355–2360.
  • T. Yurino, T. Ohkuma
    Development of Catalytic Isocyanation via Precise Reactivity Control of Ambident Reagent
    J. Synth. Org. Chem. Jpn. 2023, 81, 235–243.

2022年

  • T. Yurino, H. Yamashita, Y. Shan, Z. Wu, T. Ohkuma
    Potassium Alkoxide as an Efficient Catalyst for Nucleophilic Perfluoroalkylation: Attempt at Anion-Controlled Enantioselective Insertion of CF3 Group
    Synlett 2022, 33, 1739–1744.
  • 百合野大雅
    『ケイ素が触媒する有機合成化学の新展開』
    化学と工業 2022年4月号　支部発話題
  • T. Yurino, S. Saito, M. Ichihashi, T. Ohkuma
    Aerobic Allylic Amination Catalyzed by Pd(OAc)2/P(OPh)3 System with Low Catalyst Loading
    J. Org. Chem. 2022, 87, 2864–2872.
  • N. Arai, T. Ohkuma
    Stereoselective Construction of Cyclohepene-Fused Indoline Frameworks through Photosensitised Formal [5+2] Cycloaddition
    Tetrahedron Lett. 2022, 88, 153588.

2021年

  • T. Yurino, Y. Tange, T. Ohkuma
    Palladium-Catalyzed Nucleophilic Isocyanation for the Synthesis of α-Aryl-α-isocyanoacetoamide Derivatives”
    Bull. Chem. Soc. Jpn 2021, 94, 2155–2161
  • H. Ece, Y. Tange, T. Yurino, T. Ohkuma
    Silyl Cyanopalladate-Catalyzed Friedel–Crafts-Type Cyclization Affording 3-Aryloxindole Derivatives
    Synlett 2021, 32, 935–939.

2020年

  • N. Arai, T. Ohkuma
    Photosensitized Intramolecular [2+2] Cycloaddition of 1H-Pyrrolo[2,3-b]pyridines Enabled by the Assistance of Lewis Acids
    J. Org. Chem. 2020, 85, 15717–15725
  • 大熊　毅
    伝えることの大切さと難しさ（巻頭言）
    有機合成化学協会誌 2020, 78, 759 （８月号）
  • T. Yurino, Y. Tange, R. Tani, T. Ohkuma
    Ag2O-catalysed nucleophilic isocyanation: selecive formation of less-stable benzyic isonitriles
    Org. Chem. Front. 2020, 7, 1308–1313. (Front Cover Picture)
  • T. Yurino, T. Ohkuma
    Nucleophilic Isocyanation
    ACS Omega     2020, 5, 4719–4724. (invited manuscript)
  • T. Yurino, A. Hachiya, K. Suzuki, T. Ohkuma
    Selective Conversion of Benzylic Phosphates into Diarylmethanes through Al(OTf)3-Catalyzed Friedel–Crafts-type Benzylation
    Eur. J. Org. Chem.     2020, 2020, 2225–2232
  • T. Yurino, H. Ece, T. Ohkuma
    Friedel–Crafts-type Allylation of Phenol Derivatives Catalyzed by Silyl Cyanometallates Generated In Situ
    Asian J. Org. Chem. 2020, 9,  557–560.

2019年

  • N. Arai, T. Ohkuma
    Stereoselective Preparation of Methylenecyclobutane-fused Angular Tetracyclic Spiroindolines via Photosensitized Intramolecular [2+2] Cycloaddition with Allene
    Tetrahedron Lett. 2019, 60, 151252–151255.
  • N. Arai, Y. Okabe, T. Ohkuma
    Isomerization-Asymmetric Hydrogenation Sequence Converting Racemic β-Ylidenecycloalkanols into Stereocontrolled β-Substituted Cucloalkanols Using a Ru Catalytic System with Dual Roles
    Adv. Synth. Catal. 2019, 361, 5540-5547.
  • 大熊毅    
    ルテニウム錯体触媒を用いるイミン類の不斉水素化反応 
    触媒 2019, 61, 291–297
  • T. Yurino, R. Tani, T. Ohkuma
    Pd-Catalyzed Allylic Isocyanation: Nucleophilic N-Terminus Substitution of Ambident Cyanide
    ACS Catal. 2019, 9, 4434–4440.
  • N. Arai, T. Ohkuma
    Stereoselective Construction of Methylenecyclobutane-Fused Indolines through Photosensitized [2+2] Cycloaddition of Allene-Tethered Indole Derivatives
    Org. Lett. 2019, 21, 1506–1510.
  • 大熊毅
    「ジュッと音がする触媒を作りたい　高活性不斉水素化触媒開発奮闘記」
    化学と工業 2019, 72–3, 259–261.
  • T. Ohkuma, N. Kurono, N. Arai
    Development of Asymmetric Reactions Catalyzed by Ruthenium Complexes with Two Kinds of Ligands (Award Accounts)
    Bull. Chem. Soc. Jpn. 2019, 92, 475–504.

    *CSJのTwitterで宣伝されました（tweet 1, tweet 2）

2018年

  • N. Utsumi, N. Arai, K. Kawaguchi, T. Katayama, T. Yasuda, K. Murata, T. Ohkuma*
    Asymmetric Hydrogenation of Polysubstituted Aromatic Ketones Catalyzed by the DIPSkewphos/PICA Derivative-Ruthenium(II) Complexes
    ChemCatChem, 2018, 10, 3955–3959
  • N. Arai, T. Ohkuma
    Construction of Unique Heterocyclic Frameworks by Photochemical Reaction of 5- and 6-Membered Heteroaromatics
    Heterocycles, 2018, 96,  997–1035
    (invited review)
  • T. Ohkuma, N. Kurono, Y. Sakaguchi, K. Yamauchi, T. Yurino
    Enantioselective Cyanosilylation of Alkynyl Ketones Catalyzed by Combined Systems Consisting of Chiral Rughtnium(II) Complex and Lithium Phenoxide
    Adv. Synth. Catal. 2018, 360, 1517–1522
  • N. Arai, T. Namba, K. Kawaguchi, Y. Matsumoto and T. Ohkuma
    Chemoselectivitiy Control in the Asymmetric Hydrogenation of γ- and δ-Keto Esters into the Hydroxy Esters or the Diols
    Angew. Chem. Int. Ed. 2018, 57, 1386–1389

2017年

  • 大熊毅
    〔特集〕ノーベル賞受賞技術・理論の普及と化学工業の役割　「キラルテクノロジー：不斉水素化反応」
    化学工学 81(12), 666–669 (2017)
  • 新井則義、大熊毅
    あの身近な化合物はこうやってつくられた
    現代科学　2017年12月号 18-23
  • 新井則義、大熊毅
    有機化合物のつくりかた事始め
    現代化学　2017年11月号 17–21
  • N. Arai, T. Ohkuma
    Photochemically Promoted Aza-Diels-Alder-Type Reaction: High Catalytic Activity of the Cr(III)/Bipyridine Complex Enhanced by Visible Light Irradiation
    J. Org. Chem. 2017, 82, 7628–7636
  • N. Arai, H. Satoh, R. Komatsu, T. Ohkuma
    Double Asymmetric Hydrogenation of Linea β,β-Disubstituted α,β-Unsaturated Ketones into γ-Substituted Secondary Alcohols using a Dual Catalytic System
    Chem. Eur. J. 2017, 23, 8806–8809 (inside cover picture)
  • 百合野大雅
    水から水素を取り出して”移し替える”
    月刊化学 2017年2月号
  • T. Yurino
    Undirected Dehydrogenative Silylation of Aromatic C-H Bond
    J. Org. Synth. Chem. Jpn. 2017, 75, 64-65

2016年

  • T. Ohkuma, N. Arai
    Advancement in Catalytic Asymmetric Hydrogenation of Ketones and Imines, and Development of Asymmetric Isomerization of Allylic Alcohols
    Chem. Rec. 2016, 16, 2797–2815 (Invited Paper)
  • N. Arai, N. Onodera, T. Ohkuma
    Efficient chemoselective hydrogenation of organic azides catalyzed by palladium nanoparticles with alkyne-derived homogeneous supports
    Tetrahedron Lett. 2016, 57, 4183—4186
  • 新井則義, 大熊　毅
    光による分子活性化を利用した含ヘテロ多環系骨格構築手法の開発
    有機合成化学協会誌　2016, 74, 360–371
  • N. Kurono and T. Ohkuma,
    Catalytic Asymmertic Cyanation Reactions.
    ACS Catalysis, 2016, 6, 989–1023.
    (Invited Review)

2015年

  • 新井則義, 大熊　毅
    25.1.4 水素ガスを用いる還元法―触媒の調製と反応例
    有機合成実験法ハンドブック　第２版 (有機合成化学協会編)pp 852–859 (丸善) (2015)
  • N. Arai, N. Onodera, A. Dekita, J. Hori, and T. Ohkuma,
    Hydrogenation of Nitroarenes with Palladium Nanoparticles Stabilized by Alkyne Derivatives in Homogeneous Phase.
    Tetrahedron Letters, 2015, 56, 3913–3915.
  • N. Arai, M. Mizota, and T. Ohkuma,
    Stereoselective Preparation of Spiro[4.4] Cyclic Compounds by the Photochemical Activation of Oxazoles.
    Organic Letters, 2015, 17, 86–89.
  • N. Arai, M. Mizota, and T. Ohkuma,
    Novel Intramolecular Cyclization-Skeletal Reorganization of 2-Arylthiazoles under Photoirradiation.
    Heterocycles, 2015, 90, 607–616.
    (Isao Kuwajima’s Special Issues)

2014年

  • T. Ohkuma and N. Arai,
    “Phosphine, 1,1’-(1R)-[1,1’-binaphthalene]-2,2’-diylbis[bis(4-methylphenyl)-1 Phosphine, 1,1’-(1S)-[1,1’-binaphthalene]-2,2’-diylbis[bis(4-methylphenyl)-1” in e-EROS Encyclopedia of Reagents for Organic Synthesis, D. Crich, P. L. Fuchs, A. B. Charette, T. Rovis, Eds.; Wiley, 2014, pp 1-8.
  • Y. Sakaguchi, N. Kurono, K. Yamauchi, and T. Ohkuma,
    Asymmetric Conjugate Hydrocyanation of α,β-Unsaturated N-Acylpyrroles with the Ru(phgly)2(binap)–CH3OLi Catalyst System.
    Organic Letters, 2014, 16, 808–811.
    (SYNFACTS 510 (2014))

2013年

  • N. Arai, Y. Saruwatari, K. Isobe, and T. Ohkuma,
    Asymmetric Hydrogenation of Quinoxalines, Benzoxazines, and a Benzothiazine Catalyzed by Chiral Ruthenabicyclic Complexes.
    Advanced Synthesis & Catalysis, 2013, 355, 2769–2774.
  • N. Arai, K. Sato, K. Azuma, and T. Ohkuma,
    Enantioselective Isomerization of Primary Allylic Alcohols into Chiral Aldehyde with the tol-binap/dbapen/Ruthenium(II) Catalyst.
    Angewandte Chemie, International Edition, 2013, 52, 7500–7504.
    (Selected as a Very Important Paper (VIP))
    (Highlighted at the Inside Cover)
    (SYNFACTS 1092 (2013))
    Isomerization-Inside Cover-AGC
  • N. Arai, H. Satoh, N. Utsumi, K. Murata, K. Tsutsumi, and T. Ohkuma,
    Asymmetric Hydrogenation of Alkynyl Ketones with η6-Arene/TsDPEN–Ruthenium(II) Catalyst.
    Organic Letters, 2013, 15, 3030–3033.
  • N. Kurono, T. Katayama, and T. Ohkuma,
    Preparation of Diastereomerically Pure and Mixed (S)-PhGly/BIPHEP/Ru(II) Complexes and Their Catalytic Behavior with Li2CO3 in Asymmetric Cyanosilylation of Benzaldehyde.
    Bulletin of the Chemical Society of Japan, 2013, 86, 577–582.
    (Selected Papers)

2012年

  • N. Arai, N. Utsumi, Y. Matsumoto, K. Murata, K. Tsutsumi, and T. Ohkuma,
    Asymmetric Hydrogenation of N-Arylimines Catalyzed by
    Advanced Synthesis & Catalysis, 2012, 354, 2089-2095.
    (SYNFACTS 1229 (2012))
  • T.Ohkuma and N. Kurono
    Asymmetric Cyanation with the Chiral Ru-Li Combined Catalysts.
    Synlett, 2012, 23, 1865-1881. (Invited Account Paper)
  • M. Uemura, N. Kurono, Y. Sakai, and T. Ohkuma,
    Enantioselective Cyanosilylation of Ketones with Amino Acids/BINAP/Ruthenium(II)-Lithium Phenoxide Catalyst Systems.
    Advanced Synthesis & Catalysis, 2012, 354, 2023-2030.
  • N. Arai, K. Tanaka, and T. Ohkuma,
    Novel Intramolecular Photocyclization of α-Arylthiophene Derivatives.
    Organic Letters., 2012, 14, 1488-1491.
  • M. Uemura, N. Kurono, and T. Ohkuma,
    Enantioselective Hydrocyanation of N-Protected Aldmines.
    Organic Letters, 2012, 14, 882-885.
    (SYNFACTS 525 (2012))

2011年

  • N. Kurono, K. Ohtsuga, M. wakabayashi, T. Kondo, H. Ooka, and T. Ohkuma,
    Kinetic Resolution of Racemic α-tert-Alkyl-α-hydroxy Esters by Enantiomer-Selective Carbamoylation.
    The Journal of Organic Chemistry, 2011, 76, 10312-10318.
  • M. Akashi, N. Arai, T. Inoue, and T. Ohkuma,
    Catalyst-Controlled Diastereoselection in the Hydrogenation of Heterocycloalkyl Ketones.
    Advanced Synthesis & Catalysis, 2011, 353, 1955-1960.
    (SYNFACTS 1336 (2011))
  • K. Matsumura, N. Arai, K. Hori, T. Sito, N. Sayo, and T. Ohkuma,
    chiral Ruthenabicyclic Complexes: Precatalysts for Rapid, Enantioselective, and Wide-Scope Hydrogenation of Ketones.
    Journal of the American Chemical Society, 2011, 133, 10696-10699.
    (SYNFACTS 968(2011))
  • Kuroo. N.; Nii, N.; Sakaguchi, Y.; Uemura, M.; T.; Ohkuma, T.,
    Asymmetric Hydrocyanation of α,β-Unsaturated Ketones into β-Cyano Ketones with
    the [Ru(phgly)2(binap)]/C6H5OLi Catalyst System.
    Angewandte Chemie, International Edition, 2011, 50 (24), 5541-5544.
    (SYNFACTS 866 (2011))
  • Kurono. N.; Yoshikawa. T.; Yamasaki. M.; Ohkuma. T.,
    Enantioselective Hydrocyanation of Aldehydes Catalyzed by [Li{Ru(phgly)2(binap)}]X(X=Cl, Br).
    Organic Letters, 2011, 13 (5), 1254-1257.
  • Arai. N.; Ohkuma. T.,
    Intramolecular iminium ene reaction with Cu(I) catalysis: facile formation of 4-amino-3-methylenechromans from O-propargyl salicyladehydes and dialkylamines.
    Tetrahedron, 2011, 67 (9), 1617-1622.

2010年

  • Utsumi. N.; Tsutsumi, K.; Watanabe, M.; Murata, K.: Arai, N.; Kurono, N.; Ohkuma, T.,
    Asymmetric hydrogenation of armatic heterocyclic ketones catalyzed by the MsDPEN-Cp^Ir(III)
    complex.
    Heterocycles, 2010, 80(1), 141-147.
  • Ohkuma, T.,
    Asymmetric hydrogenation of ketones: tactics to achieve high reactivity, enanitioselectivity, and wide scope.
    Proceedings of the Japan Academy, Series B: Physical and Biological Sciences, 2010, 86(3), 202-219.
  • Kurono, N.; Uemura, M.: Ohkuma, T.,
    Asymmetric Cyanosilylation of α-Keto Esters Catalyzed by the [Ru(phgly)2(binap)]-C6H5OLi
    System.
    European Journal of Organic Chemistry. 2010, (8), 1455-1459.
  • Arai, N.; tanaka, K.; Ohkuma, T.,
    Photosensitized intramolecular cyclization of furan and non-activated alkene: pathway switching by the substituent on the furan ring.
    Tetrahedron Letters, 2010, 51 (9), 1273-1275.
  • Arai, N.: Akashi, M.: Sugizaki, S.; Ooka, H.; Inoue, T.; Ohkuma, T.;
    Asymmetric Hydrogenation of Bicyclic Ketones Catalyzed by BINAP/IPHAN-Ru(II) Complex.
    Organic Letters, 2010, 12 (15), 3380-3383.
    (SYNFACTS 1262 (2010))

2009年

  • Tsutsumi, K.; Katayama, T.; Utsumi, N;, Murata, K,; Arai, N.; Kurono, N.; Ohkuma, T.,
    Practical Asymmetric Hydrogenation of 3-Quinuclidinone Catalyzed by the XylSkewphos/PICA-Ruthenium(II) Complex.
    Organic Process Research & Development, 2009, 13 (3), 625-628.
  • Hori, J.; Murata, K.; Sugai, T.; Shinohara, H.; Noyori, R.; Arai, N.; Kurono, N.; Ohkuma, T.,
    Highly Active and Selective Semihydrogenation of Alkynes with the Palladium Nanoparticles-Tetrabutylammonuium Borohydride Catalyst System.
    Advanced Synthesis & Catalysis, 2009, 351 (18), 3143-3149.

2008年

  • Ooka, H.; Arai, N.; Azuma, K.; Kurono, N.; Ohkuma, T.,
    Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by the TolBINAP/DMAPEN-Ruthenium(II) Complex; A Significant Effect of N-Substituents of Chiral 1.2-Diamine Ligands on Enantioselectivity.
    The Journal of Organic Chemistry, 2008, 73 (22), 9084-9093.
  • Ohkuma, T.,
    Asymmetric hydrogenation of ketones using tailor-made catalyst.
    Organometallic News, 2008, (1), 8-13.
  • Kurono, N.; Kondo, T.; Wakabayahi, M.; Ooka, H.; Inoue, T.; Tachikawa, H.; Ohkuma, T.,
    Enantiomer-selective carbamoylation of racemic α-hydroxy gamma-Lactones with chiral Cu(II) Catalysts; an example of highly active Lewis acid catalyzed reaction.
    Chemistry, an Asian Journal, 2008, 3 (8-9), 1289-1297.
  • Kurono, N.; Arai, K.; Uemura, M.; Ohkuma, T.,
    [Ru(phgly)2(binap)]/Li2CO3: a highly active, robust, and enantioselective catalyst for the cyanosilylation of aldehydes.
    Angewandte Chemie, International Edition, 2008, 47 (35), 6643-6646.
    (SYNFACTS 1192 (2008))
  • Arai, N.; Suzuki, K.; Sugizaki, S.; Sorimachi, H.; Ohkuma, T.,
    Asymmetric hydrogenation of aromatic, aliphatic, and alpha, beta-unsaturated acyl silanes catalyzed by Tol-binap/Pica ruthenium(II) complexes: practical synthesis of optically active alpha-hydroxysilanes.
    Angewandte Chemie, International Edition, 2008, 47 (9), 1770-1773.
    (SYNFACTS 503 (2008))
  • Arai, N.; Azuma, K.; nii, N.; Ohkuma, T.,
    Highly enantioselective hydrogenation of arylvinyl ketones to allylic alcohols catalyzed by the tol-binap/dmapen ruthenium(II) complex.
    Angewandte Chemie, International Edition, 2008, 47 (39), 7457-7460.

2007年

  • Ohkuma, T.; Utsumi, N.; Watanabe, M.; Tsutsumi, K,; Arai, N.; Murata, K.,
    Asymmetric hydrogenation of alpha-hydroxy ketones catalyzed by MsDPEN-Cp^Ir(III) complex.
    Organic Letters, 2007, 9 (13), 2565-2567.
  • Ohkuma, T.; Tsutsumi, K.; Utsumi, N.; Arai, N.; Noyori, R.; Murata, K.,
    Asymmetric hydrogenation of alpha-chloro aromatic ketones catalyzed by η6-arene/TsDPEN-ruthenium(II) complexes.
    Organic Letters, 2007, 9 (2), 255-257.
  • Ohkuma, T.,
    Tailor-made catalysts for asymmetric hydrogenation of ketones.
    Yuki Gosei Kagaku Kyokaishi, 2007, 65 (11), 1070-1080.
  • Arai, N.; Ooka, H.; Azuma, K.; Yabuuchi, T.; Kurono, N.; Inoue, T.; Ohkuma, T.,
    General asymmetric hydrogenation of alpha-branched aromatic ketones catalyzed by TolBINAP/DMAPEN-ruthenium(II) complex.
    Organic Letters, 2007, 9 (5), 939-941.

2006年

  • Ohkuma, T.; Utsumi, N.; Tsutsumi, K.; Murata, K.; Sandoval, C.; Noyori, R.,
    The Hydrogenation/Transfer Hydrogenation Network: Asymmetric Hydrogenation of Ketones with Chiral η6-Arene/N-Tosylethylenediamine-Ruthenium(II) Catalysts.
    Journal of the American Chemical Society, 2006, 128 (27), 8724-8725.
  • Kurono, N.; Suzuki, K.; Ohkuma, T.,
    Cyanosilylation of hetero-substituted ketones catalyzed by LiCl.
    Letters in Organic Chemistry, 2006, 3 (4), 275-277.

Reviews (Monographs)

  • 百合野大雅、大熊毅
    不斉Strecker反応
    有機合成のための新触媒反応101 pp 80–81
    有機合成化学協会編　檜山爲次郎、野崎京子、中尾佳亮、中野浩司　編集
  • 百合野大雅、大熊毅
    アルケン、アルキンのシアノ官能基化
    有機合成のための新触媒反応101 pp 78–79
    有機合成化学協会編　檜山爲次郎、野崎京子、中尾佳亮、中野浩司　編集
  • 百合野大雅、大熊毅
    カルボニル基のシアノ化
    有機合成のための新触媒反応101 pp 34–35
    有機合成化学協会編　檜山爲次郎、野崎京子、中尾佳亮、中野浩司　編集
  • N. Arai, T. Ohkuma
    “Asymmetric (Transfer) Hydrogenation of Functionalized Keones”
    Asymmetric Hydrogenation and Transfer Hydrogenation,V. Ratovelomanana–Vidal, P. Phansavath Eds.; Wiley-VCH
    Weinheim, 2021, pp 55–86.
  • 新井則義、大熊毅
    水素化・水素移動反応
    『化学便覧　基礎編　改訂６版』日本化学会　編
    オンライン版
  • T. Yurino, T. Ohkuma
    Atropisomerism and Axial Chirality, Lassaletta, J. M. Ed.; World Scientific
    Singapore, 2019, pp 149–247.
  • 大熊　毅,
    ケトン類およびイミン類の環境調和型不斉水素化触媒の開発と応用.
    ファルマシア, 2015, 51, 295–299.
  • N. Arai and T. Ohkuma,
    Design of Molecular Catalysis for Achievement of High Turnover Number in Homogeneous Hydrogenation.
    Chem. Rec., 2012, 12, 284-289.
  • Ohkuma, T.; Kurono, N.,
    “BINAP” in Privileged Chiral Ligands and Catalysts, Zhou. Q.-L., Ed.; Wiley-VCH:
    Weinheim, 2011, pp 1-53.
  • Arai, N., Ohkuma, T.,
    “Reduction of Carbonyl Compound: Hydrogenation” in Science of Synthesis:
    Stereoselective Synthesis 2: Stereoselective Reactions of Carbonyl and lmino Groups,
    Molander, G. A., Ed.: Thieme: Stuttgart, 2010, pp 9-57.
  • Arai, N., Ohkuma, T.
    “Carbonyl Hydroboration” in Modern Reduction Methods, Anderson, P., Munslow, I., Eds.;
    Wiley-VCH: Weinheim, 2008, pp 159-181.
  • Ohkuma, T., Kitamura, M., Noyori, R.
    “Ligand Design for Catalytic Asymmetric Reduction” in New Frontiers in Asymmetric
    Catalysisi, Mikami K., Lautens, M. Eds.; Wiley: New Jersey, 2007, pp 1-32.
  • Ohkuma, T., Noyori, R.
    “Enantioselective Ketone and β-Keto Ester Hydrogenation (Including Mechanisms)” in The Handbook of Homogeneous Hydrogenation, de Vries, J. G., Elsevier, C. J., Eds.; Wiley-VCH: Weinheim, 2007: Vol.3 pp 1105-1163.

新聞発表

  • 化学工業日報　2020年6月11日　記事掲載
    「不斉水素化触媒を新開発　医薬品向け受託合成も活況」
  • 北海道新聞　　2013年12月26日 記事掲載
    「みんなでサイエンス　同じ分子に異なる性質？　作り分けの技術を開発」
    （本学科学技術コミュニケーション教育研究部門CoSTEP　吉田ゆかり　特任准教授　執筆）
  • 日経産業新聞　2013年7月17日　記事掲載
    「アルデヒド、１回で合成　　北海道大　新触媒で純度99％超」
  • 化学工業日報　2011年6月29日　記事掲載
    「超高速の不斉水素化触媒」